Holyoke, Edward Augustus, 1728-1829. Manuscript on smallpox inoculation by Edward Augustus Holyoke, undated. B MS Misc., Countway Library of Medicine.

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Undated manuscript written by Dr. Edward Augustus Holyoke (1728-1829) regarding inoculation. He describes the various methods of inoculation used by physicians, ways to store inoculation matter, and how to treat patients after they are infected with smallpox including administering a cooling regimen recommended by English physician Thomas Sydenham, restricting animal-based food, and encouraging moderate exercise. Holyoke also writes that he administers calomel, compound powder of crab's claws, and cream of tartar to his patients six days after smallpox eruptions first appear.

Biographical Notes

Edward Augustus Holyoke (1728-1829), A.B., 1746, Harvard College, Cambridge, Massachusetts, was a physician in Salem and the son of Harvard's ninth president, Edward Holyoke (1689-1769). He studied medicine under Thomas Berry (1695-1756) of Ipswich, Massachusetts, and once Holyoke's practice was established in Salem, he took on pupils including future Harvard Medical School professors John Collins Warren (1778-1856) and James Jackson (1777-1867). Holyoke was also the first president of the Massachusetts Medical Society from 1782 to 1784.

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when the Eruptive fever Coms on the arm Especially about the incision will inflame & Swell & is often very painful in which Case I apply a white Bread poultice with milk & oil by this means the discharge of the virulent matter will be promoted in Short the incision is to be treated in all respects Like any other inflammatory foul Ulcer till nature has thrown off the Slough when a Little Dry Lint & Com nion Cerate are all that is necessary to Com plete the Cure ––

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Dr Jactions method of prepareing the Body for the Small Pox ––

Before a medical Corse of this kind Can with propr iety be entered on I think it absolutely necessary that the Prima Vice Should be well Cleansed from those Crudities & putrid Contents with which they two often abound if therefore the patient be Enoculated in the morning I give a Cathartic portion Such as Glauberis Salts with mana or infusion of Sena Rubu rb & Cream Tart & oftimes Pulvis Cornachino tho I prefer the former ––

if the Enoculation be performed in the Evening the Purge may be given the morning following this Purge must also be repeated about the forth & Eighth Day and ofnen if there be acction Except when the following Pills are Given which must be omitted on the Purging Days

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